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The Title
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Maha Prajna Paramita Hridaya Sutra

Maha means great or large. Prajna means wisdom, more specifically intuitive wisdom. Paramita is commonly translated as "perfection" although, in a different etymological usage, it can also mean "that which has gone beyond" or "transcendent." Hridaya means "heart" but here, in the title of the sutra, it is used in the sense of a "core" or "essence" rather than a physical organ. Sutra is the spoken word; more specifically, in the Buddhist tradition, it is the sermon or the word spoken by the Buddha. Thus the full meaning of the title can be "the Great Heart of Perfect Wisdom" or "the Heart of Great Transcendent Wisdom." Or we may use poetic licence to translate it as "the Wisdom of the Great Heart of the Universe." That will certainly be in keeping with the insight offered by the sutra into sunyata as the core of the universe.